Nascent Adhesions: From Fluctuations to a Hierarchical Organization
نویسندگان
چکیده
منابع مشابه
Nascent Adhesions: From Fluctuations to a Hierarchical Organization
Integrins assemble a complex network of molecular interactions at cell-matrix adhesion sites. Fluorescence correlation microscopy has now shed light on the spatial, temporal and numerical distributions of protein complexes during assembly and stabilization of nascent adhesions.
متن کاملElastic Coupling of Nascent apCAM Adhesions to Flowing Actin Networks
Adhesions are multi-molecular complexes that transmit forces generated by a cell's acto-myosin networks to external substrates. While the physical properties of some of the individual components of adhesions have been carefully characterized, the mechanics of the coupling between the cytoskeleton and the adhesion site as a whole are just beginning to be revealed. We characterized the mechanics ...
متن کاملComparative Dynamics of Retrograde Actin Flow and Focal Adhesions: Formation of Nascent Adhesions Triggers Transition from Fast to Slow Flow
Dynamic actin network at the leading edge of the cell is linked to the extracellular matrix through focal adhesions (FAs), and at the same time it undergoes retrograde flow with different dynamics in two distinct zones: the lamellipodium (peripheral zone of fast flow), and the lamellum (zone of slow flow located between the lamellipodium and the cell body). Cell migration involves expansion of ...
متن کاملTransitioning from a hierarchical product organization to an open platform organization: a Chinese case study
Organizations around the world are designing new forms of organizing in order to deal with the challenges of advances in information technology and digitization that promote increases in customization and innovation in the face of global competition. This paper presents a case study examining the challenges experienced by a large multinational firm as it transforms from a hierarchical product o...
متن کاملHierarchical plasticity from pair distance fluctuations.
Observations, experiments and simulations often generate large numbers of snapshots of configurations of complex many-body systems. It is important to find methods of extracting useful information from these ensembles of snapshots in order to document the motion as the system evolves in time. Some of the most interesting information is contained in the relative motion of individual constituents...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 2014
ISSN: 0960-9822
DOI: 10.1016/j.cub.2014.07.061